Current Projects

The lab is focused on studying the role of chromatin structure in a diverse group of processes that happen on the molecule of DNA.The model organisms are human, yeast and flies. Research of chromatin structure, mainly at its higher levels of compaction, encompasses a large number of contemporary Molecular Biology techniques aiming at building a clearer picture of the role chromatin and its organization have on gene expression, DNA repair and recombination.

Current projects: 

Graphene oxide as universal platform for drug delivery in integrated chemo- and photo-thermal anticancer therapy

2019 – 2022 – KP-06-N31/15
Research project sponsored by the Bulgarian Science Fund

Complex ecotoxicological studies of psammophilic bivalve species from sub-littoral habitats of the Bulgarian Black Sea coast

2019 – 2022 – KP-06-N31/6
Research project sponsored by the Bulgarian Science Fund

Chromatin structure and dynamics during the lifespan of living organisms – elucidating the most intricate mechanisms that govern cellular fate

2017 - 2021 - DN 11/15
Research project sponsored by the Bulgarian Science Fund

Investigation of the ecological pressure in the Bulgarian Black sea aquatory  using the Black sea mussel Mytilus galloprovincialis Lam as a model through integrated microbiological, biochemical and molecular biology markers

2018 - 2021 - № KP-06-N21/7
Research project sponsored by the Bulgarian Science Fund

A field detector for genotoxicity from CBRN and explosive devices

2017 - 2020 - SPS MYP G5266
This project is sponsored by NATO Science for Peace and Security Programme

Natural Deep Eutectic Solvents (NADES)

2017 - 2020 - DN 19-4
Research project sponsored by the Bulgarian Science Fund

Novel Nitrogen Heterocyclic Luminophores Capable of Intramolecular Proton Transfer and Their Metal Complexes for Modern Biomedicine

2017 - 2022 - DN 19-11
Research project sponsored by the Bulgarian Science Fund

Molecular mechanisms of immune tolerance - importance for endocrine function of regulatory T-cells  

2016 - 2019 - DN 03-4
Research project sponsored by the Bulgarian Science Fund


Work is in progress and graduate students, MSc and PhD students, and post-docs with interests in the expanding field of Epigenetics and its multivariate applications in human life and health could contact Prof. Miloshev via email:

miloshev@bio21.bas.bg 
gmlab@chromatinepigenetics.com


Previous projects:

A detailed study of the role of yeast linker histone Hho1p in the processes of chromatin remodeling
Research is sponsored fully by the Bulgarian Science Fund, Grant number DMU 02/8

Environmental pollution impact on the ionomes of natural populations of yeasts and plants for monitoring purposes
Research is sponsored fully by the Bulgarian Science Fund, Grant number DVU 02/61

Study on some molecular mechanisms by which  fragile X mental retardation protein 1 in Drosophila melanogaster (dFMRP1) controls some aspects of neuronal development
Research is sponsored fully by the Bulgarian Science Fund, Grant number DID 02/35

Bulgarian young people – educated and healthy citizens of Europe
Research is sponsored fully by the Youth In Action Program, Grant number BG13/A1.2/242/R2